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HRID 60898作成日：2026年10月25日

2-Fluoro-5-(trifluoromethyl)pyridine → (2-Bromo-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

https://huagongshe.com/reaction/60898

反応式

関与物質

役割名称HCID仕込み量
反応物2-Fluoro-5-(trifluoromethyl)pyridineHCID 5463754—
反応物((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-bromo-5-methylphenyl)methanoneHCID 89739769—
生成物(2-Bromo-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanoneHCID 89739735—

反応手順

The title compound was prepared following the same general protocol as described for Example A1, using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(2-bromo-5-methylphenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 470, 472 [M]+, [M+2]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-6ca065b6940c4a09a2ddfbf3485db08f
出典メモuspto-grants-2016_09