2-Chloro-4-methoxypyrimidine → 2-(4-Methoxy-2-pyrimidinyl)-5-methylbenzoic acid

反応式

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2C=N[CH:14]=[CH:13][N:12]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].ClC1[N:23]=[C:22]([O:24][CH3:25])C=CN=1>>[CH3:25][O:24][C:22]1[CH:14]=[CH:13][N:12]=[C:11]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:10][C:6]=2[C:7]([OH:9])=[O:8])[N:23]=1

参加物

反応物 2

HCID 5889352-Chloro-4-methoxypyrimidine

HCID 811116085-Methyl-2-(2-pyrazinyl)benzoic acid

生成物 1

HCID 1177278632-(4-Methoxy-2-pyrimidinyl)-5-methylbenzoic acid

実験手順

The title compound was prepared following the same general protocol as described for 5-methyl-2-(pyrazin-2-yl)benzoic acid in Example A19, starting from 2-chloro-4-methoxypyrimidine. ESI-MS (m/z): 245 [M+1]+.

出典と根拠

ORDレコード: ord-5a715927cf5b4426a72171e2e0f791ae
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09440982B2

反応ノート

読み込み中…