Pyrrolidine-1-carbonitrile → HCID 178479317、化合物

反応式

[ClH:1].[C:2]1([CH2:8][CH2:9][C:10]([NH:12][C:13]2[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=2)[NH2:16])=[O:11])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:20]1([C:25]#[N:26])[CH2:24][CH2:23][CH2:22][CH2:21]1>ClC1C=CC=CC=1.CN(C)C1C=CN=CC=1>[ClH:1].[C:2]1([CH2:8][CH2:9][C:10]([NH:12][C:13]2[CH:14]=[C:15]([NH:16][C:25]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[NH:26])[CH:17]=[CH:18][CH:19]=2)=[O:11])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

実験手順

To a stirred suspension of the product of step (a), 2.0 g, 0.006 moles, in 35 ml of chlorobenzene was added 4-dimethylaminopyridine. To this was added 1-pyrrolidinecarbonitrile, 1.2 ml, 0.06 moles, and the reaction was heated to reflux for 4 hours. The reaction was cooled to room temperature and the solvent decanted. To the residue was added 25 ml of isopropanol and 150 ml of ethyl acetate. A solid crystallized and was collected by filtration. The above solid was then dried at 60° C. for 24 hours giving 700 mg of N-(3-(((2-phenylethyl)carbonyl)amino)phenyl)-1-pyrrolidinecarboximidamide hydrochloride, m.p. 220-221° C.