Pyrrolidine-1-carbonitrile → HCID 178479312、化合物

反応式

[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]([C:15]2[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=2)[NH2:18])=[O:14])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:22]1([C:27]#[N:28])[CH2:26][CH2:25][CH2:24][CH2:23]1>ClC1C=CC=CC=1.CN(C)C1C=CN=CC=1>[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]([C:15]2[CH:16]=[C:17]([NH:18][C:27]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[NH:28])[CH:19]=[CH:20][CH:21]=2)=[O:14])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

実験手順

To a stirred suspension of the product of step (a), 2.0 g, 0.006 moles, in 35 ml of chlorobenzene was added 4-dimethylaminopyridine. To this was added 1-pyrrolidinecarbonitrile, 1.5 ml; 0.008 moles, and the reaction was heated to reflux for 4 hours. The reaction cooled to room temperature and the solvent was decanted. To the residue was added 25 ml of isopropanol and 150 ml of ethyl acetate. A solid crystallized and was collected by filtration. The above solid was then dried at 80° C. for 24 hours to give N-[3-(((4-phenylbutyl)amino)carbonyl)phenyl]-1-pyrrolidinecarboximidamide hydrochloride, 2.3 g, m.p. 197-198° C.