2-Methoxy-2,4,6-cycloheptatrien-1-one → 2-(4-Piperonyl-1-piperazinyl)-2,4,6-cycloheptatriene-1-one

HRID 609584

反応式

HRID 609584 の反応式
CO[C:3]1[C:9](=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:11]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1>CO>[CH2:11]([N:21]1[CH2:26][CH2:25][N:24]([C:3]2[C:9](=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:23][CH2:22]1)[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1

参加物

4

反応物 2

HCID 165462-Methoxy-2,4,6-cycloheptatrien-1-oneHCID 944261-Piperonylpiperazine

生成物 1

HCID 98402272-(4-Piperonyl-1-piperazinyl)-2,4,6-cycloheptatriene-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-methoxytropone (1.36 g, 10.0 mmol) (Pietra, F. Chem Review, 1973, 73:293) and 1-piperonylpiperazine (6.61 g, 30.0 mmol) in methanol (50.0 mL) was refluxed for 16 h. After cooling to room temperature, the solvent was removed in vacuo. The residue was subjected to column chromatography using ethyl acetate as the eluent. The title compound was obtained as a yellow oil (1.24 g, 38%). MS (FAB) 325 (M+ +1).

後処理

  1. temperaturewas refluxed for 16 h
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-cff103170fa347b5a3c1344cde5b35a5
出典データセット
uspto-grants-1999_12
特許番号
US05998414

関連ノート

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