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(1-Butylpiperidin-4-yl)methanol → (1-n Butyl-4-piperidyl)methyl 5-fluoroindole-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1-Butylpiperidin-4-yl)methanol | HCID 10241250 | — |
| 反応物 | 5-Fluoroindole-3-carboxylic acid chloride | HCID 54328249 | — |
| 生成物 | (1-n Butyl-4-piperidyl)methyl 5-fluoroindole-3-carboxylate | HCID 53920547 | 30% |
反応手順
5-Fluoroindole-3-carboxylic acid chloride was reacted with (1-n butyl-4-piperidyl)methanol (D6) using the method of Example 1a to afford (1-n butyl -4-piperidyl)methyl 5-fluoroindole-3-carboxylate as an orange oil (30%), following flash chromatography on silica gel eluting with 10% ethanol/chloroform.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05998409 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-6bdb956acca849a29fee6c8b703316c2 |
| 出典メモ | uspto-grants-1999_12 |