化工社化工社 化学情報印刷レポート · 研究参考用
3-Amino-N-(4-bromophenyl)benzamide → 5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-N-(4-bromophenyl)benzamide | HCID 13609514 | — |
| 反応物 | Ethyl 1-ethyl-5-benzoyloxindole-3-carboxylate | HCID 20189466 | — |
| 生成物 | 5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide | HCID 54177968 | — |
反応手順
Prepared as in Example 1, Step A, from 5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester (U.S. Pat. No. 4,686,224) and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1) followed by trituration in ethyl acetate/hexanes. mp 139-142° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05998463 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-5135fb3f47c14e0582bed7be8351239d |
| 出典メモ | uspto-grants-1999_12 |