化工社化工社 化学情報印刷レポート · 研究参考用
Methyl chloroformate → Benzoic acid, 4-(1-methylethenyl)-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | 4-Chloro-alpha-methylstyrene | HCID 74381 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Benzoic acid, 4-(1-methylethenyl)-, methyl ester | HCID 11275336 | — |
反応手順
Preparation of the Grignard compound of 4-chloro-α-methylstyrene by means of Rieke magnesium in THF under reflux and subsequent reaction with 0.95 equivalents of methyl chloroformate at RT. Aqueous working up, extraction with ethyl acetate and column chromatography using cyclohexane/ethyl acetate 85:15 affords methyl 4-isopropenylbenzoate as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05998481 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-0c66f3c754bd40ea943d24950051c2a9 |
| 出典メモ | uspto-grants-1999_12 |