Hydrochloric Acid → 1-(6-Amino-3,5-difluoropyridin-2-yl)-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
反応式
Cl.[NH2:2][C:3]1[N:8]=[C:7]([N:9]2[C:18]3[C:13](=[C:14]([F:22])[C:15]([F:21])=[C:16]([F:20])[C:17]=3[F:19])[C:12](=[O:23])[C:11]([C:24]([O:26]CC)=[O:25])=[CH:10]2)[C:6]([F:29])=[CH:5][C:4]=1[F:30]>C(O)(=O)C>[NH2:2][C:3]1[N:8]=[C:7]([N:9]2[C:18]3[C:13](=[C:14]([F:22])[C:15]([F:21])=[C:16]([F:20])[C:17]=3[F:19])[C:12](=[O:23])[C:11]([C:24]([OH:26])=[O:25])=[CH:10]2)[C:6]([F:29])=[CH:5][C:4]=1[F:30]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To 2 ml of the mixed solution (1:1) of 4N hydrochloric acid and acetic acid was added 320 mg of ethyl 1-(6-amino-3,5-difluoropyridin-2-yl)-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux for 3 hours with stirring, and allowed to cool. The precipitate was collected by filtration, and washed with ethanol to obtain 280 mg of the title compound as a colorless powder.