Ethyl 4-[(7,8-dihydro-8,8-dimethyl-5-phenylnaphth-3-yl)ethynyl]benzoate → 4-[(7,8-Dihydro-8,8-dimethyl-5-phenylnaphth-2-yl)ethynyl]benzoic acid
反応式
CC1(C)C2C=CC([C:12]#[C:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=3)=CC=2C(C2SC=CN=2)=CC1.[CH3:29][C:30]1([CH3:59])[C:39]2[CH:38]=[CH:37][C:36](C#CC3C=CC(C(OCC)=O)=CC=3)=[CH:35][C:34]=2[C:33]([C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=2)=[CH:32][CH2:31]1>>[CH3:29][C:30]1([CH3:59])[C:39]2[CH:38]=[C:37]([C:12]#[C:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=3)[CH:36]=[CH:35][C:34]=2[C:33]([C:53]2[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=2)=[CH:32][CH2:31]1参加物
3
実験手順
Employing the same general procedure as for the preparation of 4-[(7,8-dihydro-8,8-dimethyl-5-(2-thiazolyl)naphth-3-yl)ethynyl]benzoic acid (Compound 78), 27.0 mg (0.07 mmol) of ethyl 4-[(7,8-dihydro-8,8-dimethyl-5-phenylnaphth-3-yl)ethynyl]benzoate (Compound 68) was converted into the title compound (colorless solid) using 5.9 mg (0.14 mmol) of LiOH in H2O.
出典と根拠
- ORDレコード
- ord-bdaa42fb5fc14aefad5c246051d431c8
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US05998471
反応ノート
読み込み中…