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2-(Chloromethyl)quinoline → (+/-)-cis-3-(3-Pyridyloxy)-6-(2-quinolyl)methoxy-4-chromanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Chloromethyl)quinoline | HCID 20394 | — |
| 反応物 | 2-(Chloromethyl)-6-fluoroquinoline | HCID 11241007 | — |
| 反応物 | HCID 67592373 | HCID 67592373 | — |
| 生成物 | (+/-)-cis-3-(3-Pyridyloxy)-6-(2-quinolyl)methoxy-4-chromanol | HCID 67612913 | — |
反応手順
By the methods of the preceding Example, substituting a molar equivalent of 2-chloromethylquinoline for the 6-fluoro-2-chloromethylquinoline, the title product of Example 74 (0.26 g) was converted to present chromatoqraphed title product, 0.35 g (88%), also recrystallized from isopropyl ether/CH2Cl2, m.p. 126-128° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05998451 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-98827f33d9a54363a168f60ac11001b0 |
| 出典メモ | uspto-grants-1999_12 |