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2-(Chloromethyl)-6-fluoroquinoline → cis-6-(6-Fluoro-2-quinolyl)-3-(4-methoxyphenoxy)-4-chromanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Chloromethyl)-6-fluoroquinoline | HCID 11241007 | — |
| 反応物 | HCID 67825695 | HCID 67825695 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | cis-6-(6-Fluoro-2-quinolyl)-3-(4-methoxyphenoxy)-4-chromanol | HCID 67592265 | — |
反応手順
By the method of Example 13, using flash chromatography with 35:1 CH2Cl2 :isopropanol as eluant and recrystallization from CH2Cl2 for purification of the product, the title product of Example 20 (0.20 g, 0.69 mmol) and 6-fluoro-2-chloromethylquinoline were converted to present title product, 0.104 g (34%), m.p. 151-153.5° C. MS calculated: 447.1486, found: 447.1494.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05998451 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-0f141ec7a9f34689a502e2b2857106e7 |
| 出典メモ | uspto-grants-1999_12 |