Bromine → 2-Bromo-3,4-dihydro-7-methoxy-1(2H)-naphthalenone

HRID 610394

反応式

HRID 610394 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2=[O:13])=[CH:5][CH:4]=1.[Br:14]Br>CCOCC>[Br:14][CH:9]1[CH2:8][CH2:7][C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:10]1=[O:13]

参加物

4

反応物 2

HCID 24408BromineHCID 812767-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one

生成物 1

HCID 3119062-Bromo-3,4-dihydro-7-methoxy-1(2H)-naphthalenone収率 87.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a 10° C. solution of 25 g (0.142 mol) of 7-methoxy-3,4-dihydro-1(2 H)-naphthalenone in 1 liter ether was added dropwise (maintaining reaction temperature at about 10° C.) 37.9 g (0.237 mol) of bromine. The reaction solution was concentrated on a rotating evaporator and the residue crystallized from ether to give 31.6 g (81%) of present title compound, m.p. 79-80° C.

後処理

  1. concentrationThe reaction solution was concentrated on a rotating evaporator
  2. customthe residue crystallized from ether

出典と根拠

ORDレコード
ord-4dabd2c475d042b0948df530302726ac
出典データセット
uspto-grants-1999_12
特許番号
US05998451

関連ノート

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