Hydrochloric Acid → HCID 86754917、化合物
反応式
[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].Cl>>[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].[CH3:3][N:4]([CH3:5])[CH:7]=[O:8]参加物
3
実験手順
The resultant crude mixture containing protected cefadroxil is worked up by treatment with a mixture of ice water and concentrated HCl. The phases are separated and Reextraction with water/HCl is carried out. The combined aqueous phases are treated with additional DMF, the solution is filtered and left overnight in a refrigerator. Crystalline cefadroxil dimethylformamide solvate is obtained, filtered off, washed with acetone and dried. Yield: 83%.
後処理
- customThe phases are separated
- additionThe combined aqueous phases are treated with additional DMF
- filtrationthe solution is filtered