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HRID 61074作成日：2026年10月26日

2-Chloro-5-pyrimidinecarbonitrile → 2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyridin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile

https://huagongshe.com/reaction/61074

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-5-pyrimidinecarbonitrileHCID 21473592—
反応物((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanoneHCID 117727920—
生成物2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyridin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrileHCID 117728167—

反応手順

The title compound was prepared following the same general protocol as described for Example A1, using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone and 2-chloropyrimidine-5-carbonitrile. ESI-MS (m/z): 427 [M+1]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-f7922424ac1a4db49d377e31d9179a18
出典メモuspto-grants-2016_09