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Methanol → Methyl 2-amino-4-methylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 4-Methylanthranilic acid | HCID 75316 | — |
| 生成物 | Methyl 2-amino-4-methylbenzoate | HCID 11205965 | — |
反応手順
A mixture of 2-amino-4-methylbenzoic acid (15.0 g) and concentrated sulphuric acid (20 ml) was heated under reflux with methanol for 18 hours. After removal of the solvent the residue was dissolved in dichloromethane, basified with sodium carbonate solution and the organic phase was washed with water, dried (anhydrous magnesium sulphate) and the solvent evaporated to give methyl 2-amino-4-methylbenzoate, m.p. 41-43° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05998653 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-fb508853e26b4053b9f31d5c61b56625 |
| 出典メモ | uspto-grants-1999_12 |