Hydrochloric Acid → 202466-89-5

HRID 610790ノート

反応式

HRID 610790 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH3:19])[N:15]=[C:14]([NH:20][CH3:21])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:22]>>[ClH:22].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH3:19])[N:15]=[C:14]([NH:20][CH3:21])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 5312145Ro 04-6790

生成物 1

HCID 17774509202466-89-5収率 89%

反応条件

温度
0 °C

実験手順

11.5 g (0.0373 mol) of 4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide were treated with 11.5 ml of 25 percent aqueous hydrochloric acid and stirred at 0° C. for 1 hour. The water was evaporated completely and the residue was recrystallized from ethanol/diethyl ether. There were obtained 11.8 g (89%) of 4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide hydrochloride (1:1.8) as pale yellow crystals; m.p. 175-250° C. (dec.).

後処理

  1. customThe water was evaporated completely
  2. customthe residue was recrystallized from ethanol/diethyl ether

出典と根拠

ORDレコード
ord-abc351a37f6e41d093ae84b110f64f78
出典データセット
uspto-grants-1999_12
特許番号
US05998665

反応ノート

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