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HRID 61082作成日：2026年10月26日

2-Bromo-5-chloropyridine → ((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanone

https://huagongshe.com/reaction/61082

反応式

関与物質

役割名称HCID仕込み量
反応物2-Bromo-5-chloropyridineHCID 817098—
反応物((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanoneHCID 117727820—
生成物((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanoneHCID 117727898—

反応手順

The title compound was prepared following the same general protocol as described for Example A44 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanone and 2-bromo-5-chloropyridine. MS (ESI) 453 (M+H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-f45a882333e94baf8c54c2b741c7f1c0
出典メモuspto-grants-2016_09