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HRID 61108作成日：2026年10月27日

2-Chloro-5-fluoropyrimidine → ((2S,3R)-2-(((5-Fluoropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone

https://huagongshe.com/reaction/61108

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-5-fluoropyrimidineHCID 583466—
反応物((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanoneHCID 117727920—
生成物((2S,3R)-2-(((5-Fluoropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanoneHCID 117728393—

反応手順

The title compound was prepared following the same general protocol as described for Example A1, using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone and 2-chloro-5-fluoropyrimidine. ESI-MS (m/z): 420 [M+1]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-72a798eba2a847968aa17791b3665574
出典メモuspto-grants-2016_09