Hydrochloric Acid → N,N-dimethyl-[5-(6-phenylhexyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine dihydrochloride

HRID 611081ノート

反応式

HRID 611081 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:26]>CO>[ClH:26].[ClH:26].[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 19600160N,N-Dimethyl-[5-(6-phenylhexyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl)amine

生成物 1

HCID 19600159N,N-dimethyl-[5-(6-phenylhexyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine dihydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

N,N-Dimethyl-[5-(6-phenylhexyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl)amine 0.199 g was dissolved in 2 ml of methanol; hydrogen chloride in methanol was added in excess, followed by stirring. After this mixture was concentrated, diethyl ether was added; the resulting solid was filtered and washed with diethyl ether to yield the desired product.

後処理

  1. concentrationAfter this mixture was concentrated
  2. additiondiethyl ether was added
  3. filtrationthe resulting solid was filtered
  4. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-a4752d186eb04f1ca66c0b5ac188ad8e
出典データセット
uspto-grants-1999_12
特許番号
US05998433

反応ノート

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