3-Bromo-6-methylpyridine-2-carboxylic acid → 2-(((2S,3R)-1-(3-Bromo-6-methylpicolinoyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione

HRID 61111

反応式

HRID 61111 の反応式
[CH3:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8](=[O:22])C2C=C(C)C=CC=2C2C=NN(C)C=2)[C@@H:3]1[CH2:23][N:24]1[C:32](=[O:33])[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]1=[O:34].[Br:35][C:36]1[C:37](C(O)=O)=[N:38][C:39]([CH3:42])=[CH:40][CH:41]=1>>[Br:35][C:36]1[C:37]([C:8]([N:4]2[CH2:5][CH2:6][CH2:7][C@@H:2]([CH3:1])[C@H:3]2[CH2:23][N:24]2[C:25](=[O:34])[C:26]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:32]2=[O:33])=[O:22])=[N:38][C:39]([CH3:42])=[CH:40][CH:41]=1

参加物

3

反応物 2

HCID 219014933-Bromo-6-methylpyridine-2-carboxylic acidHCID 1177277262-(((2S,3R)-3-Methyl-1-(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoyl)piperidin-2-yl)methyl)isoindoline-1,3-dione

生成物 1

HCID 1177277982-(((2S,3R)-1-(3-Bromo-6-methylpicolinoyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione

実験手順

The title compound was prepared following the same general protocol as described for 2-(((2S,3R)-3-methyl-1-(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoyl)piperidin-2-yl)methyl)isoindoline-1,3-dione in Example A1, using 3-bromo-6-methylpicolinic acid. ESI-MS (m/z): 456, 458 [M]+[M+2]+.

出典と根拠

ORDレコード
ord-22a8c44f2fdb428f8f104d8469b89f8f
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

関連ノート

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