Hydrochloric Acid → N,N-dimethyl-[6-(3-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611110ノート

反応式

HRID 611110 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[O:29][C:8]2[CH2:9][N:10]([C:13](=[O:28])[C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20](=[O:27])[C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:30]>CO.C(OCC)(=O)C>[ClH:30].[CH3:3][N:2]([CH2:4][C:5]1[O:29][C:8]2[CH2:9][N:10]([C:13](=[O:28])[C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20](=[O:27])[C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 19600018Dimethyl-[6-(3-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine

生成物 1

HCID 19600182N,N-dimethyl-[6-(3-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

N,N-Dimethyl-[6-(3-benzoylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.255 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. After this mixture was concentrated, the resulting solid was recrystallized from methanol-ethyl acetate to yield the desired product.

後処理

  1. concentrationAfter this mixture was concentrated
  2. customthe resulting solid was recrystallized from methanol-ethyl acetate

出典と根拠

ORDレコード
ord-9154ba9e11094cfd9ada1cb8eb733345
出典データセット
uspto-grants-1999_12
特許番号
US05998433

反応ノート

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