Phthalic Acid → 4-[3-(2-Carboxybenzoylamino)propylthio]pyridine

HRID 6112

反応式

HRID 6112 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1.[C:12](O)(=[O:22])[C:13]1[C:14](=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:15]([OH:17])=[O:16]>C(Cl)Cl>[C:15]([C:14]1[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=1[C:12]([NH:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)=[O:22])([OH:17])=[O:16]

参加物

4

反応物 2

HCID 1017Phthalic AcidHCID 152276954-(3-Aminopropylthio)pyridine

生成物 1

HCID 190791084-[3-(2-Carboxybenzoylamino)propylthio]pyridine収率 92.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 340 mg (2.02 mmol) of 4-(3-aminopropylthio)pyridine and 738 mg (4.98 mmol) of anhydrous phthalic acid in 5 ml of methylene chloride was stirred at room temperature for 30 minutes. The resulting crystals were filtered and dried to obtain 590 mg of the desired compound (92.3%, colorless powder), mp: 151.0°-153.3° C.

後処理

  1. filtrationThe resulting crystals were filtered
  2. customdried

出典と根拠

ORDレコード
ord-c868b3c19e0d4a2d82a6e4b451c62930
出典データセット
uspto-grants-1993_09
特許番号
US05246948

関連ノート

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