Water → N-[4-(4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzenesulphonamide

HRID 611533ノート

反応式

HRID 611533 の反応式
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:26]3[C:25]([Cl:27])=[N:24][CH:23]=[N:22][C:21]=3[N:20]([CH:28]([CH3:30])[CH3:29])[CH:19]=2)=[CH:14][CH:13]=1.C(N(CC)CC)C.O>ClCCl>[Cl:27][C:25]1[C:26]2[C:18]([C:15]3[CH:14]=[CH:13][C:12]([NH:11][S:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)(=[O:9])=[O:8])=[CH:17][CH:16]=3)=[CH:19][N:20]([CH:28]([CH3:30])[CH3:29])[C:21]=2[N:22]=[CH:23][N:24]=1

参加物

6

反応物 4

HCID 962WaterHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 195974875-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

生成物 1

HCID 19597404N-[4-(4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzenesulphonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

Benzenesulphonyl chloride (0.27 g) in dichloromethane (5 ml) was added dropwise with stirring to a solution of 5-(4-aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine (0.40 g) and triethylamine (155 mg) in dichloromethane (15 ml) at 0° C. under nitrogen. The mixture was stirred at 0° C. for one hour and then warmed to ambient temperature and stirred at this temperature for 18 hours. Water (20 ml) was added and the mixture was extracted with dichloromethane. The combined organic layers were washed with sodium bicarbonate, dried, filtered and evaporated to give N-[4-(4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzenesulphonamide

後処理

  1. temperaturewarmed to ambient temperature
  2. stirringstirred at this temperature for 18 hours
  3. extractionthe mixture was extracted with dichloromethane
  4. washThe combined organic layers were washed with sodium bicarbonate
  5. customdried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-ec17fdec137f4630aa6d22648b38799b
出典データセット
uspto-grants-1999_12
特許番号
US06001839

反応ノート

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