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2-Methoxyaniline → 4-Bromo-2-methoxyaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxyaniline | HCID 7000 | — |
| 反応物 | 2,4,4,6-Tetrabromocyclohexa-2,5-dienone | HCID 88433 | — |
| 生成物 | 4-Bromo-2-methoxyaniline | HCID 459257 | — |
反応手順
2-Methoxyaniline was brominated with 2,4,4,6-tetrabromo-2,5-cyclohexadien-1-one to give 4-bromo-2-methoxyaniline which was reacted with di-tert-butyldicarbonate in tetrahydrofuran to protect the amine group. The product was treated with butyllithium at -78° C. and then with trimethyltin chloride to give 4-tert-butoxycarbonylamino-3-methoxyphenyl trimethyl stannane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06001839 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-81be778add174383838e4f6b692fb180 |
| 出典メモ | uspto-grants-1999_12 |