Ethyl bromopyruvate → HCID 178419569、化合物

HRID 611596

反応式

HRID 611596 の反応式
[Br:1][CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:10]([NH2:16])([NH2:15])=[N:11][C:12]([NH2:14])=[S:13]>C(O)C>[BrH:1].[NH:11]([C:12]1[S:13][CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:14]=1)[C:10]([NH2:16])=[NH:15]

参加物

4

反応物 2

HCID 66144Ethyl bromopyruvateHCID 2724563Amidinothiourea

生成物 1

HCID 178419569HCID 178419569、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

13.9 ml of ethyl bromopyruvate are added to a solution of 11.81 g of 2-imino-4-thiobiuret (Aldrich) in 100 ml of ethanol and the reaction mixture is heated under reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991)). Subsequently, the mixture is cooled to room temperature and the reaction product is precipitated by the addition of 550 ml of ethyl acetate and filtered off. There are obtained 14.6 g of yellowish ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide. MS: 214 (M)+.

後処理

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991))
  3. customthe reaction product is precipitated by the addition of 550 ml of ethyl acetate
  4. filtrationfiltered off

出典と根拠

ORDレコード
ord-f50c18ad823042108b859b83988eafec
出典データセット
uspto-grants-1999_12
特許番号
US06001855

関連ノート

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