Ethyl bromopyruvate → HCID 178419569、化合物
反応式
[Br:1][CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:10]([NH2:16])([NH2:15])=[N:11][C:12]([NH2:14])=[S:13]>C(O)C>[BrH:1].[NH:11]([C:12]1[S:13][CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:14]=1)[C:10]([NH2:16])=[NH:15]参加物
4
実験手順
13.9 ml of ethyl bromopyruvate are added to a solution of 11.81 g of 2-imino-4-thiobiuret (Aldrich) in 100 ml of ethanol and the reaction mixture is heated under reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991)). Subsequently, the mixture is cooled to room temperature and the reaction product is precipitated by the addition of 550 ml of ethyl acetate and filtered off. There are obtained 14.6 g of yellowish ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide. MS: 214 (M)+.
後処理
- temperaturethe reaction mixture is heated
- temperatureunder reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991))
- customthe reaction product is precipitated by the addition of 550 ml of ethyl acetate
- filtrationfiltered off
出典と根拠
- ORDレコード
- ord-f50c18ad823042108b859b83988eafec
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06001855
反応ノート
読み込み中…