戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 61166作成日：2026年10月27日

Isoquinoline-1-carboxylic acid → 2-(((2S,3R)-1-(Isoquinoline-1-carbonyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione

https://huagongshe.com/reaction/61166

反応式

関与物質

役割名称HCID仕込み量
反応物Isoquinoline-1-carboxylic acidHCID 68092—
反応物2-(((2S,3R)-3-Methyl-1-(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoyl)piperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117727726—
生成物2-(((2S,3R)-1-(Isoquinoline-1-carbonyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117727623—

反応手順

The title compound was prepared following the same general protocol as described for 2-(((2S,3R)-3-methyl-1-(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoyl)piperidin-2-yl)methyl)isoindoline-1,3-dione in Example A1, using isoquinoline-1-carboxylic acid. ESI-MS (m/z): 414 [M+1]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-f3c70c7d7a1046a3843c24188fb49446
出典メモuspto-grants-2016_09