2-(((2S,3R)-1-(Isoquinoline-1-carbonyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione → HCID 117727788、化合物

HRID 61167

反応式

HRID 61167 の反応式
NC[C@@H]1[C@H](C)CCCN1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[C:25]1([C:35]([N:37]2[CH2:42][CH2:41][CH2:40][C@@H:39]([CH3:43])[C@H:38]2[CH2:44][N:45]2C(=O)C3C(=CC=CC=3)C2=O)=[O:36])[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][N:26]=1>>[NH2:45][CH2:44][C@@H:38]1[C@H:39]([CH3:43])[CH2:40][CH2:41][CH2:42][N:37]1[C:35]([C:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][N:26]=1)=[O:36]

参加物

3

反応物 2

HCID 1177276232-(((2S,3R)-1-(Isoquinoline-1-carbonyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

生成物 1

HCID 117727788HCID 117727788、化合物

実験手順

The title compound was synthesized following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1, using 2-(((2S,3R)-1-(isoquinoline-1-carbonyl)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione. ESI-MS (m/z): 284 [M+1]+.

出典と根拠

ORDレコード
ord-d0c4af0bc03b41128cb4bfb3fb9808a7
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

関連ノート

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