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Water → 2-Methoxy-6-methylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Methoxy-6-methyl-benzoic acid ethyl ester | HCID 591060 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Methoxy-6-methylbenzoic acid | HCID 273170 | — |
反応手順
A mixture of ethyl 6-methyl-2-methoxybenzoate (642.0 g, 3.3 mol), water (2.5 l), ethanol (4.0 l) and sodium hydroxide (270 g, 6.6 mol) is heated under reflux with stirring for 20 hours. Subsequently, ethanol is distilled off and the reaction mixture is diluted with water, acidified with concentrated hydrochloric acid. The solid material is collected by vacuum filtration, washed with water and dried yielding off-white crystals, 460.0 g (83.9%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06001883 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-52785138e4334a1d99244b55c52f6e0d |
| 出典メモ | uspto-grants-1999_12 |