Water → 2-Methoxy-6-(trifluoromethyl)benzoic acid

HRID 611720

反応式

HRID 611720 の反応式
[CH3:1][O-:2].[K+].F[C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8].O>CO>[CH3:1][O:2][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8]

参加物

5

反応物 3

HCID 962WaterHCID 6881232-Fluoro-6-(trifluoromethyl)benzoic acidHCID 23664618Potassium methoxide

生成物 1

HCID 150175332-Methoxy-6-(trifluoromethyl)benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of potassium methylate in methanol (15 ml, 15%) and 2-fluoro-6-trifluoromethylbenzoic acid (2.08 g, 0.01 mol) is heated to reflux with stirring for 40 hours. Upon cooling to room temperature water is added. The reaction mixture is filtered and the filtrate is acidified with concentrated hydrochloric acid. The solid material is collected by filtration, washed with water and dried yielding white crystals, 1.4 g (64%), mp 130-131° C.

後処理

  1. temperatureis heated
  2. temperatureto reflux
  3. additionis added
  4. filtrationThe reaction mixture is filtered
  5. filtrationThe solid material is collected by filtration
  6. washwashed with water
  7. customdried
  8. customyielding white crystals, 1.4 g (64%), mp 130-131° C.

出典と根拠

ORDレコード
ord-59a931e776544b77ae6ea1b472ab51c4
出典データセット
uspto-grants-1999_12
特許番号
US06001883

関連ノート

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