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Potassium Carbonate → Methyl 4-(3-chloropropoxy)-3-methoxybenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl Vanillate | HCID 19844 | — |
| 反応物 | 3-Chloropropyl p-toluenesulfonate | HCID 69434 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Methyl 4-(3-chloropropoxy)-3-methoxybenzoate | HCID 14407173 | 99.5% |
反応手順
A mixture of 102.4 g (411.7 mmol) of 3-chloropropyl p-toluene sulfonate, 75 g (411.7 mmol) of 4-hydroxy-5-methoxy -benzoic acid methyl ester, 75.7 g (547.5 mmol) of potassium carbonate, and 1.66 g (4.1 mmol) of methyl-tricapryl ammonium chloride in 900 ml of acetone was stirred rapidly at reflux for 18 hr. The mixture was filtered and the solvent was removed giving 106 g of the tile compound after recrystallization from a chloroform-hexane mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06002008 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-c8f2827ba64e489d8f06f816ca2b60ff |
| 出典メモ | uspto-grants-1999_12 |