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HRID 612116作成日：2026年10月27日
Dimethylformamide dimethyl acetal → Methyl 4-ethoxy-5-methoxy-2-(dimethylaminomethyleneamino)benzoate
https://huagongshe.com/reaction/612116
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | Methyl 2-amino-4-ethoxy-5-methoxybenzoate | HCID 10489373 | — |
| 溶媒 | N,N-dimethylformamide N,N-dimethylacetamide | HCID 22628260 | — |
| 生成物 | Methyl 4-ethoxy-5-methoxy-2-(dimethylaminomethyleneamino)benzoate | HCID 10779127 | 97.1% |
反応手順
A mixture of 15.056 g (66.9 mmol) methyl 2-amino-4-ethoxy-5-methoxybenzoate and 14.1 ml (100 mmol) N,N-dimethylformamide dimethylacetal was heated to 100° C. under N2. At 4.5 hours added 4.7 ml (33.3 mmol) more DMF/DMA and removed heat at 5 hours. Stripped solvent, azeotroped with toluene, and dried in vacuo, giving 18.211 g of grey-brown solid: mass spectrum (electrospray m/e): M+H=281.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06002008 |
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| 出典データセット | uspto-grants-1999_12 |
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| ORD ID | ord-b625d53183804ba2bb7b702fdf150b11 |
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| 出典メモ | uspto-grants-1999_12 |
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