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o-Aminophenethyl alcohol → HCID 22466588、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | o-Aminophenethyl alcohol | HCID 79282 | — |
| 反応物 | Pyridinium chloride | HCID 10176127 | — |
| 反応物 | 4-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile | HCID 10586676 | — |
| 溶媒 | Glycol monoethyl ether | HCID 8076 | — |
| 生成物 | HCID 22466588 | HCID 22466588 | 64.4% |
反応手順
Using an analogous procedure to that described in Example 286, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 12 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 178.3 mg (1.3 mmol) of 2-aminophenethyl alcohol to give 218.4 mg (64.4%) of the product as a pink solid, m.p 159-162° C., mass (electrospray, m/e): M+H 349.9.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06002008 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-a4fe963d86a540b1b24a71a3bfef6269 |
| 出典メモ | uspto-grants-1999_12 |