化工社化工社 化学情報印刷レポート · 研究参考用
Methane → 4-(3-Dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methane | HCID 297 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1,3-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2) | HCID 77124 | — |
| 反応物 | 4-Chloro-6-nitroquinoline-3-carbonitrile | HCID 11085690 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-(3-Dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile | HCID 22466643 | — |
反応手順
Prepared from 5.00 g of 4-chloro-6-nitroquinoline-3-carbonitrile, 5.38 g of 3-dimethylaminoaniline dihydrochloride and 5.17 g of triethylamine in the same manner as Example 377. The crude product was taken up in EtOAc, treated with Darco, filtered through Celite, evaporated and dried in vacuo (50° C.). The yield of 4-(3-dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile was 5.62 g as brick red crystals: mass spectrum (electrospray, m/e): M+H 334.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06002008 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-6cf226f92135494bbfee969ccc94b8b4 |
| 出典メモ | uspto-grants-1999_12 |