関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzamide | HCID 2331 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | (Z)-1,4-dibromobut-2-ene | HCID 5354994 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1H-Pyrrole, 1-benzoyl-2,5-dihydro- | HCID 11252283 | — |
反応手順
121 g (1 mol) of benzamide in 3 l of toluene are introduced initially, 200 g of powdered potassium hydroxide are introduced with stirring, 32 g (0.1 mol) of tetrabutylammonium bromide are added and the mixture is heated to 40° C. 243 g (1 mol) of 88% cis-1,4-dibromo-2-butene are then added dropwise in such a way that the internal temperature does not exceed 60° C. The mixture is stirred for another 5 hours at 50° C., then poured into water, and the organic phase is separated off, washed with water, dried and concentrated. The residue is distilled under reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06004956 |
|---|
| 出典データセット | uspto-grants-1999_12 |
|---|
| ORD ID | ord-cd9b215d99da4c52ba807717bb4107ea |
|---|
| 出典メモ | uspto-grants-1999_12 |
|---|
