Benzyl Bromide → 2-benzyl-4,5-dibromopyridazin-3(2H)-one

HRID 612398ノート

反応式

HRID 612398 の反応式
[Br:1][C:2]1[C:7]([Br:8])=[CH:6][N:5]=[N:4][CH:3]=1.N1NC(=[O:15])C=CC=1.[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[OH-].[K+]>CN(C=O)C>[CH2:16]([N:4]1[C:3](=[O:15])[C:2]([Br:1])=[C:7]([Br:8])[CH:6]=[N:5]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 14797Potassium HydroxideHCID 698350204,5-dibromopyridazin 2H-pyridazin-3-one

生成物 1

HCID 99026992-benzyl-4,5-dibromopyridazin-3(2H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

A mixture of 4,5-dibromopyridazin-2H-pyridazin-3-one (10 g, 40 mmol), benzyl bromide (6.84 g, 40 mmol), 8N KOH (5 mL, 40 mmol) and DMF (40 mL) was warmed up to 50° C. and reacted for 0.5 hr. The mixture was cooled to r.t., poured over H20 (500 mL) and extracted twice with Et2O (200 mL). The combined organic layers were washed with brine, dried with MgSO4 and the solvent was removed in vacuo to give the title compound which was used for next step without further purification.

後処理

  1. customreacted for 0.5 hr
  2. temperatureThe mixture was cooled to r.t.
  3. additionpoured over H20 (500 mL)
  4. extractionextracted twice with Et2O (200 mL)
  5. washThe combined organic layers were washed with brine
  6. dry with materialdried with MgSO4
  7. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-712d01db5d3a44ffb703264df5dee842
出典データセット
uspto-grants-1999_12
特許番号
US06004960

反応ノート

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