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4-Hydrazinylpyridine hydrochloride → N-[2-(4-Benzyloxyphenyl)ethylidene]-N'-pyridin-4-ylhydrazine hydrochloride monohydrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydrazinylpyridine hydrochloride | HCID 22320258 | — |
| 反応物 | 1-(4-Benzyloxyphenyl)-2-methoxyethylene | HCID 53895450 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-[2-(4-Benzyloxyphenyl)ethylidene]-N'-pyridin-4-ylhydrazine hydrochloride monohydrate | HCID 70106552 | 120.4% |
反応手順
A mixture of 1-benzyloxy-4-(2-methoxyvinyl)benzene (16.9 g), 4-hydrazinopyridine hydrochloride (11.3 g) and p-toluenesulfonic acid (0.68 g) in ethanol (200 ml) was heated under reflux for 5 hrs, with stirring. The reaction mixture was cooled, filtered, and the filtrate was concentrated in vacuo. The residue crystallized to give 15.75 g (63%) of product, mp 203-205° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06004977 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-664c4c0414f4464d83b98a997d99930d |
| 出典メモ | uspto-grants-1999_12 |