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2-Chloro-5-(trifluoromethyl)pyrimidine → (S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-5-(trifluoromethyl)pyrimidine | HCID 13317019 | — |
| 反応物 | 5-Methyl-2-(pyrimidin-2-yl)benzoic acid | HCID 44517264 | — |
| 反応物 | 2-((4,4-Difluoropiperidin-2-yl)methyl)isoindoline-1,3-dione | HCID 117728017 | — |
| 生成物 | (S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone | HCID 117727662 | — |
反応手順
The title compound was prepared following the same general protocol as described for Example A210 using 2-((4,4-difluoropiperidin-2-yl)methyl)isoindoline-1,3-dione and 5-methyl-2-(pyrimidin-2-yl)benzoic acid and Example A45 using 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 493 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440982B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-911f1feac7ab449b9ad60381a434343f |
| 出典メモ | uspto-grants-2016_09 |