化工社化工社 化学情報印刷レポート · 研究参考用
2-Iodobenzoic acid → ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Iodobenzoic acid | HCID 6941 | — |
| 反応物 | 2-Fluoro-5-(trifluoromethyl)pyridine | HCID 5463754 | — |
| 反応物 | ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone | HCID 117727638 | — |
| 生成物 | ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone | HCID 117728095 | — |
反応手順
The title compound was prepared following the same general protocol as described for Example A230 using 2-iodobenzoic acid to make ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 456 [M+1]+. 1H NMR (500 MHz, DMSO-d6) δ 8.90-6.60 (m, 11H), 4.85-2.85 (m, 5H), 2.00-0.65 (m, 8H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440982B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-aebaa0ecbad34583aab7a1654e074d21 |
| 出典メモ | uspto-grants-2016_09 |