化工社化工社 化学情報印刷レポート · 研究参考用
Glycine → 4-((4-Fluorophenyl)methylene)-2-methyl-5(4H)-oxazolone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glycine | HCID 750 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Acetic Anhydride | HCID 7918 | — |
| 生成物 | 4-((4-Fluorophenyl)methylene)-2-methyl-5(4H)-oxazolone | HCID 367073 | 78.6% |
反応手順
With stirring, 7.5 g (0.1 mol) of glycine with 6.2 g (0.075 mol) of anhydrous sodium acetate and 18.6 g (0.15 mol) of p-fluorobenzaldehyde in 60 ml of acetic anhydride are heated to 100° C. After 2 hours, the reaction is cooled and poured into water. The resulting precipitate is filtered off with suction and dried under reduced pressure. 12.1 g (59% of theory) of 2-methyl-4-(4-fluorobenzylidene)-oxazol-5-one of mp. 156° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06004992 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-6a124d6a9c454b1db81f3ca950d6acaf |
| 出典メモ | uspto-grants-1999_12 |