Ethyl isovalerate → Ethyl 2-(4-chlorobenzoyl)-3-methylbutanoate

反応式

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([O:13][C:14](=[O:19])[CH2:15][CH:16]([CH3:18])[CH3:17])[CH3:12]>>[CH2:11]([O:13][C:14](=[O:19])[CH:15]([C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:16]([CH3:18])[CH3:17])[CH3:12]

参加物

反応物 2

HCID 7945Ethyl isovalerate

HCID 85014-Chlorobenzoyl chloride

生成物 1

HCID 53811140Ethyl 2-(4-chlorobenzoyl)-3-methylbutanoate収率 82%

実験手順

4-Chlorobenzoyl chloride (2.5 ml) and isovaleric acid ethyl ester (1.5 ml) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 8(a) to obtain the title compound (2.2 g, 82%) as a colorless oil.

出典と根拠

ORDレコード: ord-ce7c8e180a094255a8830eddc510c643
出典データセット: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06005116

反応ノート

読み込み中…