Hydrochloric Acid → benzyl (2S)-2-[[(2S)-2-amino-3-(difluoromethoxy)propanoyl]amino]-3-phenyl-propanoate hydrochloride
反応式
C(OC([NH:8][C@@H:9]([CH2:31][O:32][CH:33]([F:35])[F:34])[C:10]([NH:12][C@@H:13]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:11])=O)(C)(C)C.[ClH:36]>C(OCC)C>[ClH:36].[NH2:8][C@@H:9]([CH2:31][O:32][CH:33]([F:34])[F:35])[C:10]([NH:12][C@@H:13]([CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:11]参加物
4
実験手順
Benzyl(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3 (difluoromethoxy)propanoyl]amino]-3-phenyl-propanoate (1.9 g, 3.86 mmol) was stirred in HCl, 2M in diethyl ether (12 mL), at room temperature overnight. The resulting suspension was diluted with hexanes and the filtered to collect the compound of Formula XVI(a) (1.65 g, quantitative yield) as a white solid. The product was used directly in the subsequent reaction.