Triethylamine → 4-(3-Hydroxypropylthio)pyridine

In 250 ml of methylene chloride was dissolved 22.2 g (200 mmol) of 4-mercaptopyridine and 27.9 ml (200 mmol) of triethylamine. Thereto was added 18.1 g (200 mmol) of 3-bromo-1-propanol. The mixture was stirred at room temperature for 3 hours. The reaction mixture was washed with a 1N aqueous solution of sodium hydroxide and water and dried. Then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to obtain 21.3 g of the desired compound (yield: 62.9%, yellow oil).

1. washThe reaction mixture was washed with a 1N aqueous solution of sodium hydroxide and water
2. customdried
3. distillationThen the solvent was distilled off
4. customThe residue was purified by column chromatography (eluent: ethyl acetate)

ORDレコード

ord-78e604ab97a5457d90db9847ffc8eaa3

出典データセット

uspto-grants-1993_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05246948