Hydrochloric Acid → Ethyl 4-hydroxyphenylglycine, hydrochloride

HRID 613364ノート

反応式

HRID 613364 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[ClH:13].[CH3:14][CH2:15]O>>[ClH:13].[CH2:14]([N:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1)[CH2:9][C:10]([OH:12])=[O:11])[CH3:15]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 67149N-(4-Hydroxyphenyl)glycine

生成物 1

HCID 131720465Ethyl 4-hydroxyphenylglycine, hydrochloride収率 70%

実験手順

To a suspension of 4-hydroxyphenylglycine (18.00 g, 0.11 mol) in EtOH (100 mL) was added 20% ethanolic HCl (30 mL). The mixture was heated at reflux for 14 h, then was allowed to cool and was concentrated under reduced pressure. The residue was partitioned between saturated aqueous NaHCO3 and EtOAc, and the organic extract was concentrated in vacuo to afford the title compound (15.00 g, 70%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 14 h
  3. temperatureto cool
  4. concentrationwas concentrated under reduced pressure
  5. customThe residue was partitioned between saturated aqueous NaHCO3 and EtOAc
  6. extractionthe organic extract
  7. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-83169680b8704fdea48d4c3c0732106c
出典データセット
uspto-grants-1999_12
特許番号
US06008235

反応ノート

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