Sodium methanethiolate → HCID 19592663、化合物

HRID 613465

反応式

HRID 613465 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8](Br)=[CH:7]2.[CH3:13][S-:14].[Na+]>CN(C)C=O.C(OCC)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([S:14][CH3:13])=[CH:7]2

参加物

5

反応物 2

HCID 4378561Sodium methanethiolateHCID 151125453-Bromoquinolin-8-amine

生成物 1

HCID 19592663HCID 19592663、化合物収率 66.2%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 8-amino-3-bromoquinoline (200 mg) and sodium thiomethoxide (109 mg) in N,N-dimethylformamide (2 ml) was stirred at ambient temperature for 2 days. After diluted with ethyl acetate, the resulting mixture was washed with water and brine, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on silica gel (n-hexane-ethyl acetate) to give 8-amino-3-methylthioquinoline (113 mg) as an oil.

後処理

  1. washthe resulting mixture was washed with water and brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. customevaporated in vacuo
  4. customThe residue was purified by chromatography on silica gel (n-hexane-ethyl acetate)

出典と根拠

ORDレコード
ord-802c2d8881664f5886a4efecce353081
出典データセット
uspto-grants-1999_12
特許番号
US06008230

関連ノート

読み込み中…