Acetic Anhydride → 4-Acetamido-3-methoxybenzyl alcohol

HRID 613595ノート

反応式

HRID 613595 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>CO>[C:12]([NH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11])(=[O:14])[CH3:13]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 53420748(4-Amino-3-methoxyphenyl)methanol

生成物 1

HCID 538917484-Acetamido-3-methoxybenzyl alcohol収率 73.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4-amino-3-methoxybenzyl alcohol (900 mg) in methanol was added acetic anhydride (1.8 g) under ice cooling, and the mixture was stirred for 1 hour at the same temperature. After evaporation, the residue was dissolved in ethyl acetate, and the solution was washed with sodium bicarbonate solution, water and brine, dried over magnesium sulfate and concentrated in vacuo to give 4-acetamido-3-methoxybenzyl alcohol (840 mg) as solid.

後処理

  1. customAfter evaporation
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washthe solution was washed with sodium bicarbonate solution, water and brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8912a1a0b9424178a4edcdf5a886c8e5
出典データセット
uspto-grants-1999_12
特許番号
US06008229

反応ノート

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