Carbon tetrabromide → 3-(2,2-Dibromoethenyl)-2,5-dimethoxytetrahydrofuran

HRID 613866ノート

反応式

HRID 613866 の反応式
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:20]([Br:24])(Br)(Br)[Br:21].[CH3:25][O:26][CH:27]1[CH:31]([CH:32]=O)[CH2:30][CH:29]([O:34][CH3:35])[O:28]1>C(Cl)Cl.[Zn]>[Br:21][C:20]([Br:24])=[CH:32][CH:31]1[CH2:30][CH:29]([O:34][CH3:35])[O:28][CH:27]1[O:26][CH3:25]

参加物

6

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 567310Tetrahydro-2,5-dimethoxyfuran-3-carbaldehyde

生成物 1

HCID 183804243-(2,2-Dibromoethenyl)-2,5-dimethoxytetrahydrofuran収率 55.2%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of Zn powder (1.65 g, 25.0 mmol), triphenylphosphine (6.54 g, 25.0 mmol), and CBr4 (8.30 g, 25.0 mmol) in dry CH2Cl2 (40 mL) was stirred at ambient temperature. After 24 hours, 2,5-dimethoxy-tetrahydrofuran-3-carboxaldehyde (2.00 g, 12.5 mmol) was added and an exothermic reaction ensued. After 30 minutes, pet ether (100 mL) was added and the resultant upper layer separated. The lower layer was twice diluted with CH2Cl2 (50 mL) and pet ether (50 mL), and the upper layer reserved. The combined upper layers were combined, passed through a pad of SiO2, and concentrated under reduced pressure at 30° C. or below to give 2.18 g (55%) of 3-(2,2-dibromoethenyl)-2,5-dimethoxytetrahydrofuran as a volatile colorless oil, which was a mixture of diastreomers by 1H NMR and used immediately without further purification.

後処理

  1. customan exothermic reaction
  2. waitAfter 30 minutes
  3. customthe resultant upper layer separated
  4. additionThe lower layer was twice diluted with CH2Cl2 (50 mL) and pet ether (50 mL)
  5. concentrationconcentrated under reduced pressure at 30° C. or below

出典と根拠

ORDレコード
ord-70ff169213d541b0ba03153e63bc0a69
出典データセット
uspto-grants-1999_12
特許番号
US06008243

反応ノート

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