Cyanide → 1-n-Butyl-3-(p-chloro-alpha,alpha-dimethylbenzyl)-1-ethylurea

HRID 614021

反応式

HRID 614021 の反応式
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([N:9]=[C:10]=[O:11])([CH3:8])[CH3:7])=[CH:4][CH:3]=1.[C-]#N.[CH2:16]([NH:20][CH2:21][CH3:22])[CH2:17][CH2:18][CH3:19]>C(C(C)=O)C(C)C>[CH2:16]([N:20]([CH2:21][CH3:22])[C:10]([NH:9][C:6]([CH3:8])([CH3:7])[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=1)=[O:11])[CH2:17][CH2:18][CH3:19]

参加物

5

反応物 3

HCID 5975CyanideHCID 25914ButylethylamineHCID 131183231-Chloro-4-(2-isocyanatopropan-2-yl)benzene

生成物 1

HCID 544416831-n-Butyl-3-(p-chloro-alpha,alpha-dimethylbenzyl)-1-ethylurea収率 86.2%

試薬・触媒・溶媒 1

HCID 7909Methyl Isobutyl Ketone溶媒

実験手順

A solution of 3.9 g of p-chloro-α,α-dimethylbenzyl isocyanate, prepared from the corresponding cyanide in the same way as in Synthesis Example 1, in 20 ml of methyl isobutyl ketone was added to 2.2 g of N-n-butylethylamine. The solvent was then removed by distillation under reduced pressure and the resulting crystals were recrystallized from n-hexane to obtain 5.1 g of the title compound.

後処理

  1. customThe solvent was then removed by distillation under reduced pressure
  2. customthe resulting crystals were recrystallized from n-hexane

出典と根拠

ORDレコード
ord-c2dcf5310609440cb2e68c0e1dc319f3
出典データセット
uspto-grants-1979_03
特許番号
US04143061

関連ノート

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