Benzene → 2-Cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate

HRID 614070ノート

反応式

HRID 614070 の反応式
[C:1]([C:3]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4][OH:5])#[N:2].[CH3:18][S:19](Cl)(=[O:21])=[O:20].C1C=CC=CC=1>C(N(CC)CC)C>[CH3:18][S:19]([O:5][CH2:4][C:3]([C:1]#[N:2])([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])[CH2:6][CH2:7][CH2:8][CH3:9])(=[O:21])=[O:20]

参加物

5

反応物 3

HCID 241BenzeneHCID 31297Methanesulfonyl chlorideHCID 233399042-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

生成物 1

HCID 233399252-Cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A mixture of 2-cyano-2-(2,4-dichlorophenyl)hexan-1-ol (5.6g., 0.02 mole) and methane sulfonyl chloride (2.9g., 0.025 mole) in 200 ml. of benzene is added dropwise at 10° C., 2.8g. (0.027) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 6.3g. of product.

後処理

  1. temperatureheated on a steam bath for another 30 minutes
  2. customThe precipitate formed
  3. filtrationis filtered
  4. washthe filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is evaporated
  7. customto give 6.3g

出典と根拠

ORDレコード
ord-d357bb61589c472ca22042a6a8f944c7
出典データセット
uspto-grants-1979_03
特許番号
US04143137

反応ノート

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