4-Methylmorpholine → N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester

HRID 614203ノート

反応式

HRID 614203 の反応式
Cl.[CH2:2]([O:9][C:10](=[O:24])[C@H:11]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[NH:12][C:13](=[O:16])[CH2:14][NH2:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.ClC1C=C(Cl)C(Cl)=CC=1[O:34][C:35](=O)[CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39].CN1CCOCC1>C(Cl)Cl>[CH2:2]([O:9][C:10](=[O:24])[C@H:11]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[NH:12][C:13](=[O:16])[CH2:14][NH:15][C:35](=[O:34])[CH2:36][NH:37][C:38]([O:40][C:41]([CH3:43])([CH3:42])[CH3:44])=[O:39])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 79724-MethylmorpholineHCID 12799284t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl EsterHCID 70603822glycyl-L-phenylalanine benzyl ester hydrochloride

生成物 1

HCID 54338339N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 6.1 parts glycyl-L-phenylalanine benzyl ester hydrochloride, 7.0 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 1.8 parts N-methylmorpholine in 150 parts methylene chloride is stirred overnight at room temperature. The solvents are then removed by evaporation under reduced pressure to yield the crude tripeptide. Purification by low pressure column chromatography affords pure N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester.

後処理

  1. customThe solvents are then removed by evaporation under reduced pressure
  2. customto yield the crude tripeptide
  3. customPurification by low pressure column chromatography

出典と根拠

ORDレコード
ord-51e5c6e633014b468d7fc6b39a0ba378
出典データセット
uspto-grants-1979_03
特許番号
US04144228

反応ノート

読み込み中…